Background:

This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6.

Applications:

WB, IHC

Name of antibody:

TUBB3

Immunogen:

Fusion protein of human TUBB3

Full name:

tubulin beta 3 class III

Synonyms:

CDCBM; FEOM3; TUBB4; CDCBM1; CFEOM3; beta-4; CFEOM3A

SwissProt:

Q13509

IHC positive control:

Human prostate cancer and Human liver cancer; Human colorectal cancer

IHC Recommend dilution:

250-1000

WB Predicted band size:

50 kDa

WB Positive control:

Mouse brain tissue, Rat brain tissue and Human cerebella tissue lysates

WB Recommended dilution:

5000-20000