Background:

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.

Applications:

IHC

Name of antibody:

NTRK1(Phospho-Tyr791)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 791 (P-V-Y(p)-L-D) derived from Human Trk A.

Full name:

neurotrophic tyrosine kinase, receptor, type 1

Synonyms：

MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA

SwissProt:

P04629

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100