Background:

Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.

Applications:

ELISA, WB, IHC

Name of antibody:

RCOR1

Immunogen:

Synthetic peptide of human RCOR1

Full name:

REST corepressor 1

Synonyms:

RCOR; COREST

SwissProt:

Q9UKL0

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human ovarian cancer and human lung cancer

IHC Recommend dilution:

20-100

WB Predicted band size:

53 kDa

WB Positive control:

A431,231 and PC-3 cell lysates

WB Recommended dilution:

200-1000