Background:

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.

Applications:

ELISA, WB

Name of antibody:

PIAS1

Immunogen:

Synthetic peptide of human PIAS1

Full name:

protein inhibitor of activated STAT, 1

Synonyms：

GBP; ZMIZ3; DDXBP1; GU/RH-II

SwissProt:

O75925

ELISA Recommended dilution:

2000-5000

WB Predicted band size:

72 kDa

WB Positive control:

Human testis and human placenta tissue

WB Recommended dilution:

500-2000