Background:

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

Applications:

ELISA, WB

Name of antibody:

PTK2

Immunogen:

Fusion protein of human PTK2

Full name:

protein tyrosine kinase 2

Synonyms：

FAK; FADK; FAK1; FRNK; PPP1R71; p125FAK; pp125FAK

SwissProt:

Q05397

ELISA Recommended dilution:

2000-5000

WB Predicted band size:

119 kDa

WB Positive control:

231, NIH/3T3, A431 and hela cells

WB Recommended dilution:

500-2000