Background:

This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Applications:

ELISA, IHC

Name of antibody:

USP2

Immunogen:

Fusion protein of human USP2

Full name:

ubiquitin specific peptidase 2

Synonyms：

USP9; UBP41

SwissProt:

O75604

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human cervical cancer and human thyroid cancer

IHC Recommend dilution:

50-200